C（3〜6か月） BALB/c-PI3K KO BALB/c-PI3K KO C.Cg-Pik3r1<tm1Tka>. The PI3K, phosphoinositide-3-kinase gene is a key enzyme producing phospholipid second messengers and plays an important role in various signal transduction pathways. This knockout mouse strain is useful for investigating the function of the PI3K gene. Keio University 1999年に東大の門脇 孝先生と共同で作成し、その後 C57BL/6NTac と BALB/cATac に12代戻し交配したもの C.Cg-Pik3r1<tm1Tka>/Rbrc 小安　重夫 The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Science, 283, 390-392 (1999). Nat. genet., 21, 230-235 (1999).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. <a href='https://brc.riken.jp/mus/pcr01577'>Genotyping protocol -PCR-</a> 条件を付加する。利用者は事前に寄託者の提供承諾書を得る。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。Science, 283, 390-392 (1999). Nat. genet., 21, 230-235 (1999).<br>研究成果の公表にあたって謝辞の表明を必要とする。 慶應義塾大学 Since most of homozygous females are sterile, we maintain the colony by mating heterozygous females with homozygous males. Since most of homozygous females are sterile, we maintain the colony by mating heterozygous females with homozygous males. Shigeo KOYASU RBRC01577 C (3-6 months) BALB/c-PI3K KO mouse PI3K genomic DNA, E. coli neo, HSV TK polyA Developed by Dr. Kadowaki of the University of Tokyo and backcrossed to BALB/c for 12 generations by depositor. Necessary documents for ordering:<ol><li>Approval form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_6.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_d.docx">English</A>)</li><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol><A HREF="https://www.ims.riken.jp/labo/43/index.html" target="_blank">Lab HP</A> true